The aim of the work was to improve the dissolution properties of the poorly soluble drug, Telmisartan by the liquisolid compaction technique. The study was carried out by applying full factorial design. Components of formulation such as amount of propylene glycol and ratio of carrier to coating material R were selected as independent variables and dissolution amount, hardness & disintegration time were taken as dependent variable. Liquid load factor (Lf) and excipients ratio were calculated with mathematical model to give the required amount of excipients necessary for preparing the tablets. Telmisartan liquisolid tablet formulations made, complied the different official and non-official tests. Significantly improved dissolution profile was observed for F7 as compared to that of marketed formulation as indicated by difference factor 51. The study demonstrated with confidence that the liquisolid technique is promising approach for improvement of solubility of poorly soluble drugs.
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